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[Lab] SGN BPC — VendorInvestigate came back 97.8% against a claimed 97.0%

Lab Sourced ×6 Cold Box ×2 Slow Clap ×2

Filing this under things worth writing down: SGN BPC — VendorInvestigate came back 97.8% against a claimed 97.0%.

Figures up front so nobody has to dig: 97.8% and 97.0%.

Net peptide content accounts for counterion, water and residual solvent. On some of these compounds the gap between purity and net content is substantial and entirely honest.

Purity methods differ by compound class. A gradient and wavelength developed for one peptide will not necessarily resolve the relevant impurities of another.

Happy to answer the boring questions. Those are usually the ones worth asking.

15,241 up / 11,654 down57% upvoted25 commentsid 1mklo415 Feb 2025
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25 comments

17 in this archive, depth 5

best — the order this archive was captured in

u/throwaway_9182488 points·1 year ago

Which exact molecule? That name covers more than one.

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u/rui_only_roMOD282 points·1 year ago

Asked for a catalogue number rather than removing. Common names are ambiguous here and it makes threads unusable later.

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u/bastian_aalto225 points·1 year ago

Correction: that name covers two different molecules and the thread has been discussing both as one.

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u/formulary_fighterOPappeals158 points·1 year ago

Correcting my own comment: the storage condition I quoted was for the lyophilised powder, not for solution.

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u/formulary_fighterOPappeals91 points·1 year ago·edited

a secretagogue and a fragment are not the same class of thing

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u/marit_mensa64 points·1 year ago

lyophilised and stored cold is the default for a reason

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u/formulary_fighterOPappeals33 points·1 year ago·edited

What lead time were you quoted for that line?

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u/vendorinvestigate_vic285 points·1 year ago

Small fix — that is net peptide content, not purity. Both are on the certificate and they differ substantially here.

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u/elin_trevino218 points·1 year ago

Stocked lines and made-to-order lines have different lead times and different storage histories. Both are ordinary; the difference is worth confirming before you commit.

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u/osman_ferrari126 points·1 year ago

handling and storage vary enormously across this catalogue

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u/yusuf_achebe32 points·1 year ago·edited

a mass spectrum costs little and answers the real question

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u/osman_ferrari14 points·1 year ago

That result is an area percent from an unspecified method, which is not the same as the identity confirmation being discussed.

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u/soren_osei10 points·1 year ago

Asked for identity confirmation on an unusual line and got a mass spectrum with the theoretical mass alongside. That is the answer I now look for everywhere.

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u/sequence_checkerresearch peptides-35 points·1 year ago

Storage conditions came back specific rather than generic when I asked. That told me somebody had actually done stability work.

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u/yannick_barros26 points·1 year ago

the less-tested the compound, the more the identity test matters

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u/patient_labslip_log102 points·1 year ago·edited

Stocked lines and made-to-order lines have different lead times and different storage histories.

elin_trevino is right that a purity figure without a method is not comparable to one with a method.

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u/slow_logbook_notes30163 points·1 year ago

Net peptide content on the certificate was well below the purity figure and both were honest. Chemistry, not deception.

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