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c/reconstitution·submitted 3 months ago by u/lyophile_lou

[Question] how do you actually verify dead space

Questionbranch of 7 comments

Slightly embarrassed to be asking this, but: how do you actually verify dead space. Asked WWB what volume they reconstitute to for their own stability testing and they answered in one line. Useful thing to know. Why "more water" keeps confusing people, including me for a month. The vial contains a fixed amount of…

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7 comments, started 3 months ago
u/piotr_bruun4 points·3 months ago

If your calculation produces a fraction of a unit, the concentration is wrong for your dose. Change the water volume until the numbers land on whole units.

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u/rina_bergstrom5 points·3 months ago

Are you accounting for the powder volume, or is that where the confusion is?

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u/ruben_cabrera0 points·3 months ago

Correction: that gives 5 units, not what you have written. 30mg into 2mL is 15mg/mL and the division follows from there.

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u/ilias_cabrera0 points·3 months ago

Correction: that gives 5 units, not what you have written.

Adding one thing — put the date on the label too. Concentration plus date and you can never mix two vials up.

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[deleted]1 point·3 months ago

[deleted]

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u/alcohol_aversion2 points·3 months ago

aim the stream at the glass wall, not at the cake

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u/vial_math_verasyringe math1 point·3 months ago

the number you write down is the number you will trust at 6am

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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