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c/reconstitution·submitted 1 year ago by u/quiet_reader_99

units are the most under-discussed thing on this board

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Something I keep coming back to: units are the most under-discussed thing on this board. Bacteriostatic water contains benzyl alcohol as a preservative, which is what makes repeated entry into the same vial reasonable. Plain sterile water has no preservative. If your calculation produces a fraction of a unit, the…

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7 comments, started 1 year ago
u/ledger_modmod · vetting715 points·1 year ago

The whole calculation, once, with real numbers.

You have a 15mg vial. You add 3mL of bacteriostatic water. Concentration is mass over volume: 5mg/mL. A U-100 insulin syringe is graduated at 100 units per millilitre, so one unit is 0.01mL.

To draw 0.25mg you need 0.25 divided by 5 millilitres, which is 5 units on the barrel. Write "5mg/mL" on the vial in marker before you put it away, and you never have to do this again for that vial.

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u/anya_antonsen600 points·1 year ago

That only works if the fill weight is exactly the label weight, and it usually is not exactly anything.

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u/nadia_kjaer271 points·1 year ago

That only works if the fill weight is exactly the label weight, and it usually is not exactly anything.

Adding one thing — put the date on the label too. Concentration plus date and you can never mix two vials up.

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[deleted]413 points·1 year ago

[deleted]

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u/quiet_reader_99OP0 points·1 year ago

Show the arithmetic — where did the unit figure come from?

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u/janek_ferrari1 point·1 year ago

Small fix — a U-100 syringe is 100 units per mL. If yours is marked differently it is not U-100 and the whole calculation changes.

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u/georgi_adebayo421 points·1 year ago

That only works if the fill weight is exactly the label weight, and it usually is not exactly anything.

anya_antonsen has the units point exactly right. They are a volume on the barrel and nothing else.

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The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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