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c/glp1women·posted 9 months ago by u/sterile_field_steph

[Results] 25 weeks, 12kg, and contraception was the hard part

Results Receipts ×3 Cold Box ×1

25 weeks, 12kg, and contraception was the hard part, logged the same way every week so the comparison is at least internally fair.

25 weeks and 12kg — those are the numbers, and they are the ones I am willing to defend.

Insulin resistance is a common feature in PCOS, which is why the metabolic conversation overlaps so heavily with this board. A diagnosis and a finding are still different things and the distinction matters for what the evidence says.

Hormonal variation across the cycle affects appetite, fluid retention and subjective symptom intensity independently of anything else, which is why an unannotated log can look mysterious.

I will update this if the picture changes rather than quietly leaving it up.

1,439 up / 386 down79% upvoted62 commentsid 7g6i0823 Oct 2025

62 comments

25 in this archive, depth 5

best — the order this archive was captured in

u/sulphur_burps_sue193 points·9 months ago

The one practical change that makes this board’s hardest questions tractable: annotate your log with the cycle.

Hormonal variation affects appetite, fluid and symptom intensity in its own right. Without the annotation, a log shows a dose, a week and a set of symptoms that appear to move at random. With it, patterns that were invisible become obvious in about three months.

Members here who have done it consistently report the same thing: the same dose feels genuinely different at different points, and knowing that in advance converts a confusing fortnight into an expected one. It also makes a much better document to bring to an appointment.

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u/emeka_chowdhury-34 points·9 months ago

Fertility changed faster than I expected with the weight loss. Nobody had raised it and I wish somebody had.

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u/signe_villalobos160 points·9 months ago

hair shedding follows the rate of loss, not the compound

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u/vito_beaulieu94 points·9 months ago

hair shedding follows the rate of loss, not the compound

This is the practical fix for half the confusing weeks on this board — annotate the cycle.

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u/nnt_nate106 points·9 months ago

Started logging the cycle in the same sheet as the dose. Three months later the pattern was obvious and it had been invisible before.

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u/ewan_tulloch89 points·9 months ago

Trial populations for the major programmes were not designed around the questions this board asks most often, which is why the evidence base here is genuinely thinner rather than merely harder to find.

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u/sterile_field_stephOP46 points·9 months ago

Correction: that trial did not enrol the population being discussed, so it cannot support the claim.

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u/neha_falk51 points·9 months ago

Brought the cycle-annotated log to an appointment and it changed the conversation completely.

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u/nnt_nate31 points·9 months ago

the same dose can feel different at different points in the month

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u/sterile_field_stephOP0 points·9 months ago

Is this a PCOS diagnosis or an insulin resistance finding?

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u/kenji_demir55 points·9 months ago

Have you asked a pharmacist about the absorption question specifically?

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u/rasmus_petrescu25 points·9 months ago

Telogen shedding follows a period of significant weight change rather than a specific compound, and it resolves.

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u/idris_kimani0 points·9 months ago

Started logging the cycle in the same sheet as the dose.

Agreed, and the research gap being real rather than imagined is worth saying out loud.

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u/ewan_zielinski50 points·9 months ago

Fertility can change with weight loss and improved insulin sensitivity. That is a well-described phenomenon and worth knowing about in advance rather than discovering.

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u/mateusz_mensah26 points·9 months ago

Has this been raised with whoever prescribes?

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u/vito_beaulieu13 points·9 months ago

Has this been raised with whoever prescribes?

Adding the one thing nobody warns about — fertility can change, and quickly.

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u/rasmus_petrescu40 points·9 months ago

fertility can change with weight loss and that surprises people

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[deleted]16 points·9 months ago

[deleted]

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u/vitamin_d_void4 points·9 months ago

symptom patterns can track the cycle rather than the dose

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u/sterile_field_stephOP1 point·9 months ago

Perimenopause and all of this at once, and there is essentially nothing written about the combination anywhere.

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u/blunt_coldbox_202411 points·9 months ago

Anything involving pregnancy, contraception efficacy or fertility planning belongs with a clinician. That is not a disclaimer, it is where the answers actually are.

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u/coa_forgery_watch16 points·9 months ago

The hair shedding was the thing that frightened me most and the thing that mattered least. It stopped.

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u/devils_advocate_d43 points·9 months ago·edited

Questions about oral contraceptive absorption and gastric emptying are legitimate pharmacology questions with product-specific answers. A pharmacist can answer them properly; a board cannot.

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u/tired_ledger_ftw11 points·9 months ago

The questions that leave this board, and where they go.

Anything about pregnancy, planning a pregnancy, or contraception efficacy goes to a clinician. Absorption questions about a specific oral product go to a pharmacist, who can look it up in minutes. Fertility changes with weight loss are well described and worth raising with whoever prescribes, in advance rather than afterwards.

What stays here usefully: experience, cycle-annotated patterns, the vocabulary, and the collective knowledge that a research gap exists. That is a genuinely valuable set of things and it is a smaller set than people arriving here expect. Nothing on this board is medical advice and on this board that is not a formality.

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u/joaquin_wojcik0 points·9 months ago

Careful — anything touching pregnancy is not a board question in any form.

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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