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c/glp1women·posted 1 year ago by u/gustav_lindholm

contraception — 16 things I got wrong before I got it right

Caution Clean Column ×9

contraception — 16 things I got wrong before I got it right. Change my mind, genuinely — I have no stake in being right about this.

Perimenopause and all of this at once, and there is essentially nothing written about the combination anywhere.

The same dose genuinely feels different at different points in the month for me. Took a year to notice and it was in the log the whole time.

Fertility changed faster than I expected with the weight loss. Nobody had raised it and I wish somebody had.

Research-use-only material is not approved for human use and nothing here should be read as a recommendation to use it.

6,545 up / 5,785 down53% upvoted48 commentsid 12t71w24 Apr 2025

48 comments

15 in this archive, depth 5

best — the order this archive was captured in

u/hair_shed_hannah179 points·1 year ago

Trial populations for the major programmes were not designed around the questions this board asks most often, which is why the evidence base here is genuinely thinner rather than merely harder to find.

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u/karl_fischer_kev75 points·1 year ago

Small fix — insulin resistance is a feature commonly seen in PCOS, not a synonym for it.

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u/aleksi_eriksen22 points·1 year ago

That trial did not enrol the population you are asking about, so it cannot answer this.

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u/enzo_fonseca0 points·1 year ago

The hair shedding was the thing that frightened me most and the thing that mattered least. It stopped.

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u/ignacio_kuipers1 point·1 year ago

Is this a PCOS diagnosis or an insulin resistance finding?

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[deleted]1 point·1 year ago

[deleted]

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u/gustav_lindholmOP1 point·1 year ago

Are you asking about the compound, the weight loss, or both?

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u/gustav_lindholmOP100 points·1 year ago

Are you logging the cycle alongside the dose?

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u/emeka_chowdhury-17 points·1 year ago

How many cycles has the pattern held for?

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u/elin_lindqvist1 point·1 year ago

How many cycles has the pattern held for?

Disagreeing with this line: the absorption question has a product-specific answer and a pharmacist has it.

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u/foam_head_fred-25 points·1 year ago

symptom patterns can track the cycle rather than the dose

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u/gustav_lindholmOP1 point·1 year ago

Where in the cycle does this fall, if you are tracking it?

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u/honest_syringe_20251 point·1 year ago

Started logging the cycle in the same sheet as the dose. Three months later the pattern was obvious and it had been invisible before.

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u/jarno_karlsen83 points·1 year ago

Hormonal variation across the cycle affects appetite, fluid retention and subjective symptom intensity independently of anything else, which is why an unannotated log can look mysterious.

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u/kenji_demir0 points·1 year ago

Went looking for trial data on the specific question asked here and found the population had not been enrolled.

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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