[Question] how do you actually verify pharmacology
how do you actually verify pharmacology. I would rather ask a basic question now than get this wrong quietly for two months. GLP-1 receptor agonism acts both peripherally — insulin secretion in a glucose-dependent way, slowed gastric emptying — and centrally, on appetite regulation. The central component is the…
Same view. Tolerance developing to the gastric effect while the appetite effect persists explains most of what the side-effect board reports.
Same view.
Disagreeing with this specific inference — that is a preclinical result being read as human pharmacology.
incretin effect first, then everything else in this board makes sense
Disagreeing with this specific inference — that is a preclinical result being read as human pharmacology.
Agreed — and it is why the central and peripheral stories are complementary rather than rival.
Right — mechanism gives you a direction. It never gives you an effect size and people use it as though it does.
The half-life explanation was the thing that made weekly dosing intuitive for me rather than arbitrary.
Cosigning on GIP. The genuinely interesting thing is that the biology is not settled and the clinical result is nonetheless robust.