appetite is the most under-discussed thing on this board
appetite is the most under-discussed thing on this board. Change my mind, genuinely — I have no stake in being right about this. GIP receptor biology is genuinely unsettled — there is a live argument about agonism versus antagonism at the receptor — and the clinical results are robust regardless, which is an…
Tolerance to the gastric effect develops with continued exposure while the appetite effect largely persists. That single fact explains most of the "it settles but it still works" pattern the side-effect board reports.
Read the primary paper after arguing about the summary for a fortnight. The discussion section said almost the opposite of what the thread had concluded.
mechanism explains a direction, not a magnitude
mechanism explains a direction, not a magnitude
Disagreeing with this specific inference — that is a preclinical result being read as human pharmacology.
Small fix — it slows gastric emptying, it does not halt it, and the distinction matters for the mechanism you are proposing.
gastric emptying slows, it does not stop
Not convinced by the linearity assumption. Dose-response in this class is not linear and the trials show it.
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Agreed that receptor distribution is the key to the side-effect map. It is not a mystery, it is anatomy.
That study was in a rodent model. Worth stating, since the thread has been reading it as human data.
read the discussion section, that is where the honesty lives