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c/glp1science·submitted 9 months ago by u/sanne_delgado

[Question] mechanism — what am I missing here

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mechanism — what am I missing here. I am not trying to be the "source?" guy. I would just like a source. Glucose-dependent insulin secretion is why hypoglycaemia risk is low as monotherapy: the effect scales with glycaemia rather than acting unconditionally. Tolerance to the gastric effect develops with continued…

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u/ingrid_correia114 points·9 months ago

Is there any human data on that mechanism yet?

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u/analog_alphabet91 points·9 months ago

a mechanism you can state is not a mechanism you have demonstrated

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u/ingrid_correia76 points·9 months ago

the peripheral and central stories are not in competition

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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