[Discussion] data logger is doing more work than we give it credit for
data logger is doing more work than we give it credit for. It is the sort of thing everyone half-believes and nobody writes down. Once in solution, the relevant risks are hydrolysis, aggregation and, for some sequences, oxidation. Refrigeration slows all three; freezing a solution introduces a separate risk at the…
Agreed. The dry powder is the robust state; it is the solution that needs the care.
Agreed.
This is the distinction that resolves most threads here — powder and solution are different problems.
Small fix — refrigerated, not frozen, once it is in solution.
Agreed.
Disagreeing with this line only: freezing a reconstituted vial is not a safe default.
Do you know what storage condition the stability statement covers?
That is the ambient temperature at the destination, not the temperature inside the box. The logger measures the second one.