cold chain — 23 things I got wrong before I got it right
cold chain — 23 things I got wrong before I got it right. It is the sort of thing everyone half-believes and nobody writes down. Wrote the reconstitution date on the vial for the first time last year. Have never once since wondered how old a solution is. Split an order across two months deliberately to compare summer…
Lyophilisation removes the water that drives most degradation pathways. That is why the dry cake is comparatively robust and the reconstituted solution is not.
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What was the packaging — rigid outer, gel packs, anything insulating?
Yes — reconstitution date on the vial. It is the number you will want and cannot reconstruct.
Correction: that stability figure covers the lyophilised powder, not the reconstituted solution. Different claim entirely.
Kept a vial at room temperature for eleven days by accident. Tested it out of guilt. It was fine.
Moved everything off the fridge door after reading a thread here and my temperature log immediately got boring.
Right, and asking what the stability statement was written against is one line of email that reframes everything.