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c/coa·submitted 7 months ago by u/ignacio_silva

[Discussion] can we stop arguing about related substances until somebody posts a number

Discussionbranch of 6 comments

Question in the title, detail here: can we stop arguing about related substances until somebody posts a number. Started keeping a folder of every certificate I have been sent. The ones that itemise impurities are a small group and they are mostly the same suppliers. The four things a certificate must carry, and what…

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6 comments, started 7 months ago
u/tidy_vialdrawer_pls247 points·7 months ago

What does the method line actually say? Not the technique — the column and the gradient.

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[deleted]175 points·7 months ago

[deleted]

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u/rohan_steiner69 points·7 months ago

Asked for the storage condition behind the stability statement. Got it in a sentence. It is a two-line email and almost nobody sends it.

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u/ignacio_silvaOP0 points·7 months ago

Area percent or net peptide content? They answer different questions.

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How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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