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c/coa·submitted 1 months ago by u/anders_kuusela

[PSA] batch is not what most of this community thinks it is

COAbranch of 9 comments

batch is not what most of this community thinks it is. It comes up every few weeks and the answer has not changed. The document I was worried about turned out to be a re-issue with a later creation date. Asked, got the original, entirely ordinary. Asked for the storage condition behind the stability statement. Got it…

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9 comments, started 1 months ago
u/ignacio_silva185 points·1 months ago

The PDF creation date being later than the analysis date is usually a re-issue or a re-export. It is worth one question and it is not evidence of anything on its own.

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u/anya_moreau66 points·1 months ago

What does the method line actually say? Not the technique — the column and the gradient.

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u/wanjiru_varga77 points·1 months ago

the related substances line is where the story is

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u/katrin_girard21 points·1 months ago

This. Area percent answers "what fraction of what the detector saw was the peak I wanted", and people read it as "how much peptide is in the vial".

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u/halima_boateng22 points·1 months ago

Pushing back a little: a missing field is usually presentation, not concealment. Ask for the full document before drawing conclusions.

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u/janek_ferrari50 points·1 months ago

axis labels included, always

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u/gallbladder_gary16 points·1 months ago

redact your own name, never the batch details

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u/laila_wojcik5 points·1 months ago

redact your own name, never the batch details

gallbladder_gary has the distinction right — one is a fraction of the detector signal, the other is a fraction of the mass.

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u/coa_collectorarchivist24 points·1 months ago

HPLC-UV and LC-MS answer different questions

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How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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