[Caution] CagriSema trial ratios are fixed-dose, do not extrapolate to self-mixing
CagriSema trial ratios are fixed-dose, do not extrapolate to self-mixing — a position I have arrived at slowly and would like tested. Reading the trial literature on this without misleading yourself. Separate the monotherapy arms from the combination arms before you do anything else. They report different effect…
the monotherapy numbers are modest and that is not the point
the monotherapy numbers are modest and that is not the point
lane_map_larry is right that the evidence base here is thin. Conclusions should be held loosely.
Yes. The combination is where the interesting effect sizes are, and the monotherapy arms read very differently.
Went looking for independent results on this and found a handful across the whole site. That is the honest state of the evidence.
Went looking for independent results on this and found a handful across the whole site.
Disagreeing with this line: that figure is from a combination arm and is being quoted as monotherapy.
amylin analogue, different receptor family, different story