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c/cagrilintide·submitted 2 years ago by u/amara_kuipers

am I the only one who found amylin harder than the injections

Discussionbranch of 10 comments

am I the only one who found amylin harder than the injections, and I want the answer with the reasoning attached rather than just the conclusion. Combination and monotherapy arms must be read separately. Efficacy and tolerability both differ substantially between them and summaries routinely blur the two. Amylin is…

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10 comments, started 2 years ago
u/runa_grimaldi95 points·2 years ago

Independent purity data on this compound is sparse compared with the older molecules, simply because far fewer members have paid for testing. Sparse data means wide uncertainty, not a verdict.

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u/emeka_beaulieu27 points·2 years ago

Read the combination paper twice before saying anything here. The monotherapy and combination arms tell genuinely different stories.

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u/rekha_mwangi7 points·2 years ago·edited

Is there any independent purity data on this compound that you have seen?

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u/sten_rautio31 points·2 years ago

Agreed — it is an amylin analogue and importing intuitions from the incretin boards produces confident nonsense.

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u/viktor_erdogan19 points·2 years ago

amylin and GLP-1 are not redundant pathways

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u/liv_kuipers11 points·2 years ago

Correction: that is the combination programme, not the monotherapy readout. Different arms, different numbers.

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u/zaid_grimaldi11 points·2 years ago

REDEFINE is the combination programme

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u/mateusz_adebayo7 points·2 years ago

REDEFINE is the combination programme

Adding the standing caveat — nothing here is approved standalone and research material is not for human use.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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