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c/cagrilintide·submitted 10 months ago by u/zaid_balogun

[Meta] proposal — a flair for cagrilintide posts

Trial Databranch of 7 comments

proposal — a flair for cagrilintide posts, and it will stay as it is unless somebody makes the case to change it. Combination and monotherapy arms must be read separately. Efficacy and tolerability both differ substantially between them and summaries routinely blur the two. Amylin is co-secreted with insulin and acts…

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7 comments, started 10 months ago
u/egfr_watcher21 points·10 months ago

Yes. The combination is where the interesting effect sizes are, and the monotherapy arms read very differently.

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u/sanne_laurent14 points·10 months ago

Correction: that is the combination programme, not the monotherapy readout. Different arms, different numbers.

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u/lane_map_larrylogistics8 points·10 months ago

Small fix — amylin analogue, not a GLP-1 analogue. The whole mechanism argument changes on that word.

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u/zaid_balogunOP9 points·10 months ago

How many separate lots has anyone here tested?

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u/nz_unfunded7 points·10 months ago

Not convinced. Amylin signalling is not a GLP-1 pathway and the mechanism you are proposing conflates them.

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u/zeynep_duarte13 points·10 months ago·edited

Yes.

egfr_watcher is right that the evidence base here is thin. Conclusions should be held loosely.

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u/zaid_balogunOP10 points·10 months ago

read the combination arms separately from the monotherapy arms

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