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c/cagrilintide·submitted 1 year ago by u/amara_kuipers

is it normal to get food noise at week 47

Questionbranch of 8 comments

is it normal to get food noise at week 47, and the part I actually want to talk about is at the bottom. Read the combination paper twice before saying anything here. The monotherapy and combination arms tell genuinely different stories. The tolerability tables were more informative than the headline numbers, which is…

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8 comments, started 1 year ago
u/incretin_ivypharmacology21 points·1 year ago

Nothing containing this compound is approved as a standalone product, and research-use-only material is not approved for human use.

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u/helga_vermeulen17 points·1 year ago

That result is preclinical. Worth flagging, since the thread has been reading it as human data.

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u/freya_baptista4 points·1 year ago

Went looking for independent results on this and found a handful across the whole site. That is the honest state of the evidence.

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u/amara_kuipersOP3 points·1 year ago

Small fix — amylin analogue, not a GLP-1 analogue. The whole mechanism argument changes on that word.

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u/sten_rautio2 points·1 year ago·edited

Small fix — amylin analogue, not a GLP-1 analogue.

Disagreeing with this line: that figure is from a combination arm and is being quoted as monotherapy.

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u/amara_kuipersOP12 points·1 year ago

Which trial and which readout?

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u/rt_shift_reggie10 points·1 year ago

do not assume the dosing intuitions from the GLP-1 boards transfer

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u/erez_perrin6 points·1 year ago·edited

Which trial and which readout?

This is the distinction that keeps this board honest — different axis, not a stronger version of the same one.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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