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c/cagrilintide·submitted 1 year ago by u/hedda_aguirre

[Discussion] amylin is doing more work than we give it credit for

Discussionbranch of 8 comments

amylin is doing more work than we give it credit for. Not a hot take, just something I have not seen said plainly here. Sent a vial to Medutest because there was almost nothing on file for this compound. 99.5% against a claimed 99.0%, and I posted it because the log needs entries. The tolerability tables were more…

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8 comments, started 1 year ago
u/tomas_kimani18 points·1 year ago

Cosigning on the thin independent data. Fewer members test this, so the bands are wider and should be treated that way.

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u/helga_vermeulen11 points·1 year ago

Cosigning on the thin independent data.

This is the distinction that keeps this board honest — different axis, not a stronger version of the same one.

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u/egfr_watcher3 points·1 year ago

satiety signalling rather than incretin signalling

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u/rania_salinas1 point·1 year ago

independent purity data on this compound is thin

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u/incretin_ivyMOD7 points·1 year ago

Standing reminder: nothing here is approved standalone, research material is not for human use, and no dosing schedules for other members.

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u/crosspost_bot_no2 points·1 year ago

nothing containing this is approved as a standalone product

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u/viktor_nkemelu4 points·1 year ago

Small fix — amylin analogue, not a GLP-1 analogue. The whole mechanism argument changes on that word.

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u/ilias_kaufmann2 points·1 year ago

Bought small deliberately because the evidence base is thin. That felt like the only defensible approach.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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