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c/bpc157·submitted 1 year ago by u/ayesha_erdogan

small win: pentadecapeptide stopped being a problem at week 74

Cautionbranch of 7 comments

Reporting in. small win: pentadecapeptide stopped being a problem at week 74. Assumed regulatory status was static and it was not. Checked again this year and the answer had changed where I live. Went and read the primary rodent papers after arguing about a summary for a week. They are much narrower than the threads…

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7 comments, started 1 year ago
u/chain_confirm_cpayments58 points·1 year ago

The evidence base, described honestly, which almost no summary of it does.

The published literature is overwhelmingly preclinical and largely in rodent models. The individual papers are generally more modest in their claims than the summaries that circulate. Human clinical trial evidence for the claims most often repeated in these threads is very limited.

That is not an argument that nothing is happening in the preclinical work — some of it is genuinely interesting. It is an argument that the distance between "this happened in a rodent model" and "this will happen in a person" is large, uncertain, and crossed silently in nearly every confident post on this board, including some of mine from two years ago.

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u/osman_brandt15 points·1 year ago

The evidence base, described honestly, which almost no summary of it does.

Disagreeing with this line: that paper is in a rodent model and it is being quoted as a human result.

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[deleted]10 points·1 year ago

[deleted]

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u/sofia_ferreira43 points·1 year ago

It is a fifteen-residue peptide with a published sequence, which makes synthesis straightforward and makes identity verification the meaningful test rather than an optional extra.

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u/enzo_danquah88 points·1 year ago·edited

Do you have the mass spectrum?

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u/marta_trevino39 points·1 year ago

the tendon claims are the most repeated and the least evidenced

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u/nurse_ish_202532 points·1 year ago

the tendon claims are the most repeated and the least evidenced

Adding the standing caveat — research material is not approved for human use, wherever you are.

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About c/bpc157

BPC-157 as it actually is: a pentadecapeptide with a genuinely interesting rodent tendon-and-gut literature, near-zero controlled human data, a naming and sequence mess in the supply chain, and a regulatory status that changed sharply in several countries.

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