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c/bloodwork·submitted 6 months ago by u/thermal_mass_tom

my TSH moved and I cannot work out whether ferritin is why

Discussionbranch of 9 comments

my TSH moved and I cannot work out whether ferritin is why. I have gone back and forth on this for months. How to make a panel worth comparing, which is most of the value people leave on the table. Standardise the conditions: same lab, same fasting state, same rough time of day, same point in the week, similar…

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9 comments, started 6 months ago
u/liv_okafor27 points·6 months ago

assay method matters, especially between different labs

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u/edit_for_clarity7 points·6 months ago

The confounding problem, stated plainly, because this board keeps stepping on it.

Substantial weight loss moves lipids, liver enzymes, insulin sensitivity markers and several others in its own right. If you are losing weight while taking something, any change in those markers has at least two candidate explanations and you cannot separate them from your own panel.

What you can do is standardise, take a baseline, keep the series long, and be honest in your posts about what is and is not attributable. The threads that say "this compound did X to my ApoB" almost never have the design to support the claim, mine included.

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u/britt_marchand3 points·6 months ago

The confounding problem, stated plainly, because this board keeps stepping on it.

edit_for_clarity is right that a reference interval is not a target. It is a description of a population.

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u/coldchain_karencold chain2 points·6 months ago

That is a non-fasting value and the interval you are comparing it against is a fasting one.

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u/emil_agyeman1 point·6 months ago

Disagree with reading anything into that. One value, one morning, and you changed two other things in the same window.

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u/micro_bump_mick3 points·6 months ago

ApoB is the one worth adding if you only add one

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u/liver_enzyme_lizMOD17 points·6 months ago

Left up. It is a question about how to compare panels, not a request for interpretation.

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u/tidy_vialdrawer_watch6 points·6 months ago

bring the numbers to someone qualified to read them

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u/elin_varga1 point·6 months ago

Added ApoB to the panel after a thread here. It told me something the standard lipid panel had been hiding.

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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