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Single comment threadYou are looking at one branch of stalled for 6 weeks at 2.5mg and I refuse to panic this time — 19 comments in the full submission. View in context.
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c/bloodwork·submitted 3 months ago by u/ahmed_fonseca

stalled for 6 weeks at 2.5mg and I refuse to panic this time

Discussionbranch of 7 comments

stalled for 6 weeks at 2.5mg and I refuse to panic this time. I have gone back and forth on this for months. Hard numbers: 6 weeks and 2.5mg. Anything softer than that is flagged as an impression. Nobody here can interpret your panel and this comment is not doing so. What a board can usefully do is help you ask…

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7 comments, started 2 months ago
u/janek_ferrari17 points·2 months ago

Repeat testing before acting is standard practice for a reason: regression to the mean does a lot of work on single outlying values.

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u/blank_injection-26 points·2 months ago

The confounding problem, stated plainly, because this board keeps stepping on it.

Substantial weight loss moves lipids, liver enzymes, insulin sensitivity markers and several others in its own right. If you are losing weight while taking something, any change in those markers has at least two candidate explanations and you cannot separate them from your own panel.

What you can do is standardise, take a baseline, keep the series long, and be honest in your posts about what is and is not attributable. The threads that say "this compound did X to my ALT" almost never have the design to support the claim, mine included.

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u/britt_marchand0 points·2 months ago

How many weeks between the two measurements?

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u/lina_almeida1 point·2 months ago

ApoB counts atherogenic particles rather than the cholesterol they carry, which is why it can diverge from LDL-C and why it is the addition most worth making.

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u/lipid_panel_larrybloodwork1 point·2 months ago

Careful — that is a question for whoever ordered the panel, and nobody in this thread can answer it responsibly.

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u/laila_yilmaz1 point·2 months ago

Not convinced by the attribution. Weight loss alone moves that marker and you have no way to separate the two.

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u/peptidemeter_pat1 point·2 months ago

assay method matters, especially between different labs

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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