[Discussion] ApoB is doing more work than we give it credit for
ApoB is doing more work than we give it credit for. It is the sort of thing everyone half-believes and nobody writes down. Tracked fasting insulin against the weight trend for a year. The correlation was much weaker than I expected and that was worth knowing. How to make a panel worth comparing, which is most of the…
Different laboratories use different assay platforms with different calibration. Comparing across labs adds a systematic offset that is invisible on the report.
Reference intervals are typically the central 95% of a reference population. By construction one person in twenty falls outside one on any given test without anything being wrong.
Added ApoB to the panel after a thread here. It told me something the standard lipid panel had been hiding.
Added ApoB to the panel after a thread here.
amara_dziedzic is right that a reference interval is not a target. It is a description of a population.
Agreed on assay changes. A lab switching platforms between your draws is invisible unless you ask.
Substantial weight loss independently moves lipids, liver enzymes and several other markers. Attributing a change to a compound while losing weight is confounded by design.
That is a non-fasting value and the interval you are comparing it against is a fasting one.