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c/bloodwork·posted 2 years ago by u/diego_almeida

stalled for 13 weeks at 2.4mg and I refuse to panic this time

Baseline Sourced ×3 Long Haul ×2

stalled for 13 weeks at 2.4mg and I refuse to panic this time. I have gone back and forth on this for months.

13 weeks and 2.4mg. Those are measured, not estimated, and not rounded up in my favour.

Brought the whole set to my clinician rather than one flagged value. Completely different conversation.

Tracked eGFR against the weight trend for a year. The correlation was much weaker than I expected and that was worth knowing.

Happy to answer the boring questions. Those are usually the ones worth asking.

3,107 up / 627 down83% upvoted13 commentsid 107iab19 May 2024

13 comments

8 in this archive, depth 4

best — the order this archive was captured in

u/diego_almeida471 points·2 years ago

Substantial weight loss independently moves lipids, liver enzymes and several other markers. Attributing a change to a compound while losing weight is confounded by design.

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u/vito_chowdhury683 points·2 years ago

ApoB counts atherogenic particles rather than the cholesterol they carry, which is why it can diverge from LDL-C and why it is the addition most worth making.

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u/milos_trevino166 points·2 years ago

Compared two draws across two labs and spent a week worrying before finding out the assays were different.

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u/diego_almeidaOP109 points·2 years ago

Correction: that marker is reported in different units by different labs, which explains the tenfold difference you are seeing.

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u/hedda_adeyemi314 points·2 years ago

Different laboratories use different assay platforms with different calibration. Comparing across labs adds a systematic offset that is invisible on the report.

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u/jarno_karlsen154 points·2 years ago

Different laboratories use different assay platforms with different calibration.

hedda_adeyemi is right that a reference interval is not a target. It is a description of a population.

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u/nabila_bakken233 points·2 years ago·edited

Repeat testing before acting is standard practice for a reason: regression to the mean does a lot of work on single outlying values.

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u/diego_almeidaOP91 points·2 years ago

a single TSH outside range is a reason to repeat, not to panic

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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