u/thermal_mass_tom

Thinking out loud about this: phase 2 biopsy endpoints, and what "resolution" means. The honest evidence position, written out so this board does not drift. Phase 2…

the MASH thing finally clicked for me and I want to write it down, which sounds obvious until you try to state the evidence for it. Independent purity results for this…

proposal — a flair for VendorInvestigate posts — posting the reasoning in public because a policy you cannot inspect is just a preference. Started buying small…

my TSH moved and I cannot work out whether ferritin is why. I have gone back and forth on this for months. How to make a panel worth comparing, which is most of the…

Something I keep coming back to: my ALT moved and I cannot work out whether dual agonist is why. Imaging-derived liver fat fraction is a surrogate. It correlates with…

28 weeks on 10mg, full numbers, ask me anything boring. This is a description of what happened to me and not a plan for anybody else. Numbers, in the order they matter:…

VendorInvestigate is the most under-discussed thing on this board — a position I have arrived at slowly and would like tested. Started buying small deliberately, tested…

The title is the argument: order records — 5 things I got wrong before I got it right. Here is the rest of it. What a batch record should carry: the lot identifier, the…

the hepatic fat advice in here is 2 years out of date. Change my mind, genuinely — I have no stake in being right about this. The relevant figures are 2 years, and they…

Something I keep coming back to: we are measuring constipation at the wrong time and calling it noise. Nobody warned me about early fullness and I would have liked the…