u/renzo_asante

Bought small because the evidence base is early. That is the only defensible position I could construct.

Got a request for information and treated it as a seizure for two days before actually reading it. It was neither dramatic nor difficult.

Total transit decomposes into first mile, international leg, clearance and last mile. Only the first two are meaningfully under the shipper’s control and most reported variance sits in the last two.

Lost money to a shop that had nothing verifiable on file anywhere. Posting so that somebody searching that name finds this.

Yes — histological endpoints are a far harder bar than the surrogate measures people are used to quoting.

read the histology endpoint definitions before quoting a response rate

this board is small because the compound is early

the last mile is where most of the variance lives

Asked somebody qualified locally rather than relying on this board. Best forty minutes I have spent on the topic.

What lead time were you quoted at checkout?

Yes — median rather than best case. The fastest anybody ever got is not a plan.

Asked here what the difference was between the imaging and biopsy endpoints and got a genuinely excellent answer.

Same lane, four orders, 16 to 6 days, all four within a couple of days of the quote. That consistency is the actual finding.

Total transit decomposes into first mile, international leg, clearance and last mile. Only the first two are meaningfully under the shipper’s control and most reported variance sits in the last two.