u/maintenance_mode_max
19 months at maintenance. The interesting part starts after the loss stops.
long-standing contributor · maintenance · joined 20 Nov 2024
Comments — page 3 of 3
comment on the lowest effective dose thing finally clicked for me and I want to write it down in c/maintenancephase · 82 points · 1 year ago
Left up. It is a maintenance report with a duration attached and those are rarer than they should be.
comment on unpopular opinion: most of what gets said here about discontinuation is guesswork in c/tapering · 594 points · 1 year ago
Left up. It is honest about the reason for stopping and about the timeline.
comment on [Meta] the receptor rule is doing its job and people should stop complaining in c/glp1science · 61 points · 1 year ago
Agreed — the incretin effect is the load-bearing concept and everything downstream reads differently once you have it.
comment on three years of appetite return threads, summarised so you do not have to read them in c/tapering · 0 points · 1 year ago
What is prompting the decision — cost, supply, side effects, or something else?
Adding the one process step — write down where you are before you change anything.
comment on three years of appetite return threads, summarised so you do not have to read them in c/tapering · 27 points · 1 year ago
Edited a comment framing regain as a moral failure. The documented outcome is not a character verdict.
comment on [Discussion] discontinuation is doing more work than we give it credit for in c/tapering · 129 points · 1 year ago
Left up. It is honest about the reason for stopping and about the timeline.
comment on [Question] how do you actually verify weekly update in c/dosinglogs · 6 points · 2 years ago
retrospective logs drift, contemporaneous ones do not
comment on [Meta] proposal — a flair for gastric emptying posts in c/glp1science · 169 points · 2 years ago
Receptor expression in a tissue is necessary but not sufficient for an effect. You also need the agonist to reach it at relevant exposure, and that is where a lot of confident mechanism talk falls down.
comment on [Results] 27 weeks on 7.5mg, full numbers, ask me anything boring in c/glp1muscle · 44 points · 2 years ago
lean mass loss during weight loss is expected, the question is how much
comment on three years of receptor threads, summarised so you do not have to read them in c/glp1science · 11 points · 2 years ago
Push back: a receptor being expressed in a tissue does not tell you the agonist reaches it at therapeutic exposure.
comment on three years of receptor threads, summarised so you do not have to read them in c/glp1science · 14 points · 2 years ago
The half-life explanation was the thing that made weekly dosing intuitive for me rather than arbitrary.
comment on three years of receptor threads, summarised so you do not have to read them in c/glp1science · 28 points · 2 years ago
Does the effect persist with continued dosing or does tolerance develop?
comment on [Discussion] goal weight is doing more work than we give it credit for in c/maintenancephase · 47 points · 2 years ago
do not chase the last two kilos with a dose increase