2.8k
[PSA] ALT is not what most of this community thinks it is
ALT is not what most of this community thinks it is. That is the post. The justification is underneath. Time of day, fasting state, hydration and recent exercise all…
u/copay_card_cc
Manufacturer savings programmes: eligibility fine print, month by month.
member · joined 11 Jun 2024
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Overview — page 3 of 3
comment on genuine question about tirzepatide that I am slightly embarrassed to ask in c/tirzepatide · 17 points · 1 year ago
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
comment on genuine question about tirzepatide that I am slightly embarrassed to ask in c/tirzepatide · 172 points · 1 year ago
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
comment on [Results] 47 weeks, 15kg, and GIP was the hard part in c/tirzepatide · 10 points · 1 year ago
SURMOUNT-1 landed around 21% at 72 weeks on the top arm
comment on goal weight — my 23-week log, condensed into one table in c/maintenancephase · 43 points · 1 year ago
Push back: that is not a plateau, that is maintenance. You have arrived and you are describing it as a failure.
comment on goal — my 3-week log, condensed into one table in c/progresspics · 27 points · 1 year ago
the first person to notice was me, months after it started
comment on help me understand compounding, I have read the wiki twice in c/glp1aus · 98 points · 1 year ago
Yes — the shortage database is the source. The news coverage of it is downstream and usually a week behind.
comment on [Discussion] the GIP advice in here is 2 years out of date in c/tirzepatide · 234 points · 1 year ago
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
comment on my fasting insulin moved and I cannot work out whether Zepbound is why in c/tirzepatide · 1.6k points · 2 years ago
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
comment on my fasting insulin moved and I cannot work out whether Zepbound is why in c/tirzepatide · 763 points · 2 years ago
Correction to my own post above — I said 12.5mg and I have been on 5mg since the spring. Same argument, wrong number.
6.7k
my fasting insulin moved and I cannot work out whether Zepbound is why
Posting this as a discussion rather than a claim: my fasting insulin moved and I cannot work out whether Zepbound is why. Vials and pens carry the same molecule; what…
comment on [Results] 19 weeks on 0.25mg, full numbers, ask me anything boring in c/maintenancephase · 128 points · 2 years ago
Dose reduction and interval extension are different interventions. Halving the dose keeps the rhythm and lowers the level; stretching keeps the level and lowers the frequency, with a lower trough.
comment on [Results] 30 weeks on 1.7mg, full numbers, ask me anything boring in c/maintenancephase · 391 points · 2 years ago
Maintenance is the phase with the least published guidance and the most individual variation, which is precisely why board consensus here is worth less than usual.
comment on ALT — 4 things I got wrong before I got it right in c/bloodwork · -31 points · 2 years ago
That is a non-fasting value and the interval you are comparing it against is a fasting one.
5.9k
ALT — 4 things I got wrong before I got it right
Posting this as a discussion rather than a claim: ALT — 4 things I got wrong before I got it right. Why so many single values look alarming and turn out to be nothing.…
comment on how much of what we believe about dose stretching actually comes from regain threads in c/maintenancephase · 0 points · 2 years ago
What is the plan if the drift continues for another month?
comment on how much of what we believe about dose stretching actually comes from regain threads in c/maintenancephase · 1 points · 2 years ago
Correction: that trial measured regain after withdrawal, not failure of the drug during treatment. Very different claim.
1k
how much of what we believe about dose stretching actually comes from regain threads
Asking properly rather than in a comment on somebody else’s thread: how much of what we believe about dose stretching actually comes from regain threads. On stopping,…
comment on nobody warned me about nausea and I would have liked the warning in c/maintenancephase · -7 points · 2 years ago
What is the plan if the drift continues for another month?
comment on anyone else notice baseline labs kicking in around week 7 in c/bloodwork · 1 points · 2 years ago
Correction: that marker is reported in different units by different labs, which explains the tenfold difference you are seeing.
1.4k
anyone else notice baseline labs kicking in around week 7
anyone else notice baseline labs kicking in around week 7. This is a description of what happened to me and not a plan for anybody else. Why so many single values look…
comment on [Question] tirzepatide — what am I missing here in c/tirzepatide · 1 points · 2 years ago
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
comment on [Meta] the SURMOUNT rule is doing its job and people should stop complaining in c/tirzepatide · 30 points · 2 years ago
SURMOUNT-1 landed around 21% at 72 weeks on the top arm