[Question] tirzepatide — what am I missing here
tirzepatide — what am I missing here. If this has been answered properly somewhere, link me and I will delete.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
Research-use-only material is not approved for human use and nothing here should be read as a recommendation to use it.
best — the order this archive was captured in
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
Push back: "gentler than sema" is a population statement.
bastian_eriksen is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.
the four-week step schedule is the label, not folklore
the appetite effect is blunter than sema, in a good way, most weeks
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads.
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
Not sure about this bit.
Saving this one. It is the clearest statement of the stall problem I have read here.
pens and vials are the same molecule, the price is the difference
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
the trials titrated on a calendar, real people titrate on symptoms
hold the dose that works, the ladder is not a leaderboard
- 1the appetite effect is blunter than sema, in a good way, most weeks9 comments in this branch · started by u/quiet_moderator
- 2SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change.…7 comments in this branch · started by u/tarek_lokken