[Paper] SURMOUNT-4 withdrawal arm, read the appendix not the abstract
SURMOUNT-4 withdrawal arm, read the appendix not the abstract. Change my mind, genuinely — I have no stake in being right about this.
Started keeping the trial identifiers straight in a note file because I kept mixing up two programmes in the same sentence.
Quoted a figure here confidently, got asked whether it was ITT, went and checked, and it was not. Learned something.
Read a press release and the publication three months apart. The hedging in the second one was substantial.
Please do not ask me what dose you should be on. I genuinely do not know and neither does anyone else here.
best — the order this archive was captured in
Open-label extensions lose their randomisation. Anybody still enrolled at week 104 is a selected group and the numbers describe that group.
Spent an evening with the appendix tables and found the subgroup detail that the entire thread had been speculating about.
What was the discontinuation rate?
Went looking for the registered protocol to see whether the endpoint had changed. It had not, which was reassuring and worth checking.
That is a relative risk reduction. Quoting it without the absolute numbers overstates the case considerably.
Correction: SURMOUNT is the obesity programme and SURPASS is the diabetes one. The figure you quoted belongs to the other one.
SURPASS is the diabetes programme and reports glycaemic endpoints
A confidence interval is the range of effects compatible with the data. Two trials with overlapping intervals have not disagreed, whatever their point estimates look like next to each other.