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c/trialwatch·submitted 1 year ago by u/marit_laurent

[Question] how do you actually verify SURPASS

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how do you actually verify SURPASS. I would rather ask a basic question now than get this wrong quietly for two months. The discontinuation numbers were the most useful thing in the paper for me and they were in a supplementary table. Argued for a week about a result and then read the limitations section, which…

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10 comments, started 1 year ago
u/prior_auth_painappeals68 points·1 year ago

Same. A press release is a claim about a result; the publication is the result.

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u/naomi_ekstrom18 points·1 year ago

a mean is not a promise

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u/ms_fragmenter15 points·1 year ago

phase 2 finds a dose, phase 3 measures the effect

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u/formulary_fighterappeals12 points·1 year ago

intention to treat versus completers changes the number substantially

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u/marit_laurentOP7 points·1 year ago·edited

Which trial, and which arm?

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u/alcohol_aversion0 points·1 year ago

That is the 68-week readout, not the 72-week one. Different trial, different duration.

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u/marit_laurentOP13 points·1 year ago

read the endpoint before you read the headline

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u/adaeze_weiss10 points·1 year ago

Not convinced. Cross-trial comparison between two programmes with different populations and designs is not a comparison.

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u/rina_bergstrom8 points·1 year ago

Do you have the publication or the press release?

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u/nordic_pricing4 points·1 year ago

Yes — the interval is the finding. A point estimate with a wide interval is a hypothesis in a nice font.

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