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c/tirzepatide·submitted 1 year ago by u/incretin_ivy

[Results] 66 weeks on 15mg, full numbers, ask me anything boring

Resultsbranch of 12 comments

Six-word version is the title — 66 weeks on 15mg, full numbers, ask me anything boring — and the rest is context. 66 weeks and 15mg. Those are measured, not estimated, and not rounded up in my favour. SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and…

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12 comments, started 1 year ago
u/emil_barros138 points·1 year ago

if 7.5 is working, 10 is not automatically better

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u/quiet_moderatorMOD80 points·1 year ago

Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.

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u/throwaway_wl202639 points·1 year ago

week 6 is early to draw any conclusion at all

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u/incretin_ivyOPpharmacology23 points·1 year ago

Did you come to this from sema, and if so how long was the gap?

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u/gustav_vermeulen19 points·1 year ago

Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.

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u/dexa_twice_yearlybody comp76 points·1 year ago

if 7.5 is working, 10 is not automatically better

Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.

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[deleted]27 points·1 year ago

[deleted]

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u/priya_guerrero56 points·1 year ago

Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.

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u/sten_palacios25 points·1 year ago·edited

Came off sema and onto tirz with a two-week gap.

Saving this one. It is the clearest statement of the stall problem I have read here.

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u/tarek_kirchner23 points·1 year ago

Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.

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u/noor_hovland11 points·1 year ago

stepping every four weeks is a ceiling on speed, not a schedule you must hit

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u/bastian_ekstrom14 points·1 year ago

Right.

This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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