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Single comment threadYou are looking at one branch of genuine question about tirzepatide that I am slightly embarrassed to ask — 65 comments in the full submission. View in context.
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c/tirzepatide·submitted 1 year ago by u/throwaway_wl2026

genuine question about tirzepatide that I am slightly embarrassed to ask

Trial Databranch of 7 comments

genuine question about tirzepatide that I am slightly embarrassed to ask. If this has been answered properly somewhere, link me and I will delete. Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.…

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7 comments, started 1 year ago
u/emil_okwuosa246 points·1 year ago

Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.

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u/copay_card_cc172 points·1 year ago

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.

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u/throwaway_wl2026OP95 points·1 year ago

That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.

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u/hair_shed_hannah79 points·1 year ago

Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.

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u/ahmed_fonseca63 points·1 year ago

the trials titrated on a calendar, real people titrate on symptoms

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u/blunt_coldbox290 points·1 year ago

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme.

This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.

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u/zeynep_zielinski-13 points·1 year ago

the muscle cramps profile is genuinely gentler than people expect coming from sema

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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