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c/tirzepatide·submitted 1 year ago by u/crosspost_bot_no

[PSA] GIP is not what most of this community thinks it is

Resultsbranch of 11 comments

Explainer, as requested in the last thread: GIP is not what most of this community thinks it is. Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate. The four-week interval in the label is a minimum.…

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11 comments, started 1 year ago
u/kaia_cabrera76 points·1 year ago

Not sure that follows. You went up a step and changed your training in the same fortnight.

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u/nordic_pricing51 points·1 year ago

Did you come to this from sema, and if so how long was the gap?

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u/hub_opssite staff28 points·1 year ago

sulphur burps are the signature complaint and they are not dangerous

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u/mikkel_ogunleye13 points·1 year ago

the trials titrated on a calendar, real people titrate on symptoms

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u/titration_marshalmod · c/semaglutide9 points·1 year ago

the trials titrated on a calendar, real people titrate on symptoms

Saving this one. It is the clearest statement of the stall problem I have read here.

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u/taper_off_tabitha26 points·1 year ago

The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 10 is not a fair reading.

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u/mikkel_kimani9 points·1 year ago

Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.

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u/copay_card_cc51 points·1 year ago

if 7.5 is working, 10 is not automatically better

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u/slow_logbook_ftw60 points·1 year ago

the four-week step schedule is the label, not folklore

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u/laila_yilmaz31 points·1 year ago

a lot of people plateau nicely at 10mg and never need 15

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u/dario_vermeulen19 points·1 year ago

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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