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c/tirzepatide·submitted 11 months ago by u/blunt_coldbox29

SURMOUNT: what the trials say vs what this community says

Resultsbranch of 7 comments

SURMOUNT: what the trials say vs what this community says. Change my mind, genuinely — I have no stake in being right about this. Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan. SURMOUNT-1 ran 72…

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7 comments, started 11 months ago
u/mikkel_ogunleye213 points·11 months ago

Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.

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u/gustav_vermeulen172 points·11 months ago

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.

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u/quiet_moderatormod105 points·11 months ago·edited

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme.

gustav_vermeulen is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.

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u/priya_guerrero30 points·11 months ago

a lot of people plateau nicely at 10mg and never need 15

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u/ferritin_low10 points·11 months ago

stepping every four weeks is a ceiling on speed, not a schedule you must hit

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u/slow_logbook_ftw137 points·11 months ago·edited

Which week did the appetite change actually land for you?

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u/nz_unfunded81 points·11 months ago

Does constipation follow the day after the shot, or is it spread across the week?

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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