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c/tirzepatide·submitted 11 months ago by u/blunt_coldbox29

SURMOUNT: what the trials say vs what this community says

Resultsbranch of 7 comments

SURMOUNT: what the trials say vs what this community says. Change my mind, genuinely — I have no stake in being right about this. Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan. SURMOUNT-1 ran 72…

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7 comments, started 11 months ago
u/two_mil_or_one237 points·11 months ago

Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.

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u/blunt_coldbox29OP163 points·11 months ago

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

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u/blunt_coldbox29OP101 points·11 months ago

That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.

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u/blunt_coldbox29OP-6 points·11 months ago

Are you comparing yourself with the trial mean or with the people who post the most?

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u/hugo_bergstrom1 point·11 months ago

if 7.5 is working, 10 is not automatically better

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u/neha_falk0 points·11 months ago

Are you comparing yourself with the trial mean or with the people who post the most?

Saving this one. It is the clearest statement of the stall problem I have read here.

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u/copay_card_cc1 point·11 months ago

Same experience with the appetite effect being flatter across the week rather than front-loaded.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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