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Single comment threadYou are looking at one branch of GIP agonism explained like i am five, please — 52 comments in the full submission. View in context.
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c/tirzepatide·submitted 11 days ago by u/ferran_mensah

GIP agonism explained like i am five, please

Labbranch of 8 comments

GIP agonism explained like i am five, please — a position I have arrived at slowly and would like tested. Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate. Held 7.5 for five months. Everyone kept…

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8 comments, started 10 days ago
u/titration_marshalmod · c/semaglutide53 points·10 days ago

hold the dose that works, the ladder is not a leaderboard

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u/sten_palacios39 points·10 days ago

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

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u/hub_opssite staff33 points·9 days ago

17kg over 92 weeks, never went past 10mg, and food noise stayed mild the whole way. Posting because the loud threads are all 15mg.

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u/throwaway_titration23 points·10 days ago

Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.

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u/two_mil_or_one10 points·9 days ago

Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.

This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.

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u/taper_off_tabitha4 points·9 days ago

stepping every four weeks is a ceiling on speed, not a schedule you must hit

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u/kaia_wojcik30 points·10 days ago

Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.

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u/ewan_marchand7 points·10 days ago

2.5 is the starter dose and it is not meant to be the dose that works

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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