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c/tirzepatide·submitted 6 months ago by u/gentle_correction

[Meta] proposal — a flair for 15mg posts

Trial Databranch of 7 comments

Housekeeping: proposal — a flair for 15mg posts. 15mg — those are the numbers, and they are the ones I am willing to defend. The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm. Held 7.5…

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7 comments, started 6 months ago
u/titration_marshalmod · c/semaglutide475 points·6 months ago

It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.

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u/swirl_dont_shakereconstitution187 points·6 months ago

That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.

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u/gentle_correctionOPnice about it353 points·6 months ago

The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.

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u/slow_logbook_ftw292 points·6 months ago

Yes — 10mg being a genuine landing place for a lot of people is underrated. There is no medal for 15.

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u/titration_marshalmod · c/semaglutide530 points·6 months ago

Correction to my own post above — I said 5mg and I have been on 7.5mg since the spring. Same argument, wrong number.

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u/alcohol_aversion-25 points·6 months ago

2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.

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[removed]1 point·6 months ago

[removed by moderator]

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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