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c/tirzepatide·submitted 10 days ago by u/kaia_cabrera

[Discussion] "tirz is stronger than sema" needs a comparator dose or it means nothing

Discussionbranch of 6 comments

"tirz is stronger than sema" needs a comparator dose or it means nothing. Making the case below, and I expect to lose some of it in the comments. Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved. Held 7.5 for five months. Everyone kept…

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6 comments, started 9 days ago
u/dexa_twice_yearlyMOD68 points·9 days ago

Removed the conversion table. There is no published equivalence between the two molecules and posting one as fact is exactly the kind of thing that gets copied for years.

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u/slow_logbook_ftw45 points·9 days ago

the appetite effect is blunter than sema, in a good way, most weeks

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u/kaia_cabreraOP-37 points·9 days ago

Have you held a step for longer than the four-week minimum at any point?

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u/kaia_cabrera56 points·9 days ago

the four-week step schedule is the label, not folklore

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u/mikkel_ogunleye25 points·9 days ago

the four-week step schedule is the label, not folklore

kaia_cabrera is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.

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[removed]17 points·9 days ago

[removed by moderator]

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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