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c/tirzepatide·submitted 1 year ago by u/elin_varga

anyone else notice GIP kicking in around week 81

Titrationbranch of 6 comments

anyone else notice GIP kicking in around week 81, logged the same way every week so the comparison is at least internally fair. Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it. The distribution matters more than the mean. In the trial…

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6 comments, started 1 year ago
u/cormac_pereira50 points·1 year ago

Yes — 10mg being a genuine landing place for a lot of people is underrated. There is no medal for 15.

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u/incretin_ivyMOD27 points·1 year ago

Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.

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u/elin_vargaOP-7 points·1 year ago

Have you held a step for longer than the four-week minimum at any point?

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u/throwaway_titration-9 points·1 year ago

the appetite effect is blunter than sema, in a good way, most weeks

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u/elin_vargaOP1 point·1 year ago

That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.

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u/elin_vargaOP17 points·1 year ago

Correction to my own post above — I said 2.5mg and I have been on 15mg since the spring. Same argument, wrong number.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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