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c/tirzepatide·submitted 2 years ago by u/piotr_nascimento

tirzepatide: the version I wish someone had shown me in week 1

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tirzepatide: the version I wish someone had shown me in week 1. This is a description of what happened to me and not a plan for anybody else. 20kg over 46 weeks, never went past 10mg, and constipation stayed mild the whole way. Posting because the loud threads are all 15mg. The distribution matters more than the…

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8 comments, started 2 years ago
u/curious_panel_only204 points·2 years ago

week 7 is early to draw any conclusion at all

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u/thyroid_tangent126 points·2 years ago

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.

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u/teodor_szabo29 points·2 years ago·edited

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme.

Saving this one. It is the clearest statement of the stall problem I have read here.

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u/discount_math_dm22 points·2 years ago

Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.

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u/tidy_vialdrawer_pls15 points·2 years ago

the reflux profile is genuinely gentler than people expect coming from sema

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u/ignacio_vanhecke36 points·2 years ago

Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.

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u/throwaway_wl2026130 points·2 years ago

sulphur burps are the signature complaint and they are not dangerous

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u/piotr_nascimentoOP99 points·2 years ago

Correction to my own post above — I said 12.5mg and I have been on 10mg since the spring. Same argument, wrong number.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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