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Single comment threadYou are looking at one branch of my fasting insulin moved and I cannot work out whether Zepbound is why — 38 comments in the full submission. View in context.
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c/tirzepatide·submitted 2 years ago by u/copay_card_cc

my fasting insulin moved and I cannot work out whether Zepbound is why

Resultsbranch of 7 comments

Posting this as a discussion rather than a claim: my fasting insulin moved and I cannot work out whether Zepbound is why. Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate. The four-week interval in…

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7 comments, started 2 years ago
u/incretin_ivypharmacology528 points·2 years ago

It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.

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u/tove_vasquez359 points·2 years ago

Does fatigue follow the day after the shot, or is it spread across the week?

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u/signe_villalobos0 points·2 years ago

the four-week step schedule is the label, not folklore

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u/ahmed_fonseca0 points·2 years ago

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.

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u/amara_halonen1 point·2 years ago

Pen or vial? The step sizes available differ and it changes this answer.

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u/signe_villalobos1 point·2 years ago

week 9 is early to draw any conclusion at all

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u/copay_card_ccOP763 points·2 years ago

Correction to my own post above — I said 12.5mg and I have been on 5mg since the spring. Same argument, wrong number.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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