genuine question about SURMOUNT that I am slightly embarrassed to ask
genuine question about SURMOUNT that I am slightly embarrassed to ask. If this has been answered properly somewhere, link me and I will delete.
Switching from semaglutide, since three people asked in this thread alone.
There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that the first month after a switch is often flat, that the appetite effect feels differently shaped rather than simply stronger, and that starting at the bottom of the ladder again is the common approach.
None of that is a recommendation. It is what the threads say, and the threads are not a clinic.
Week 73 was the first time the scale moved after a five-week stall. I changed nothing in that window.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Ask me anything specific. Anything general I will probably get wrong.
best — the order this archive was captured in
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
the four-week step schedule is the label, not folklore
hold the dose that works, the ladder is not a leaderboard
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
dual agonist, so the GIP arm is doing something the sema threads will not tell you about
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.
Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.
switching from sema is not a dose conversion, there is no clean equivalence
stepping every four weeks is a ceiling on speed, not a schedule you must hit
What step are you on and how long have you been there?
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
- 1hold the dose that works, the ladder is not a leaderboard12 comments in this branch · started by u/gentle_correction