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c/t2dglp1·submitted 1 year ago by u/osman_ferrari

what changed for me between month 11 and month 20

Questionbranch of 8 comments

The title is the whole question — what changed for me between month 11 and month 20 — but here is why I am asking. Certain conditions affect A1c independently of glycaemia. If a result looks inconsistent with the sensor data, that is a question for whoever manages your care rather than for this board. The diabetes…

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8 comments, started 1 year ago
u/bianca_demir26 points·1 year ago

Right, and the diabetes programmes report glycaemic endpoints. Quoting an obesity trial result here is answering a different question.

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u/a1c_arcT2D18 points·1 year ago

Incretin-based agents stimulate insulin secretion in a glucose-dependent manner, which is why hypoglycaemia risk with them alone is low. Risk rises with agents that act independently of glycaemia.

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u/reship_roulette12 points·1 year ago

That A1c change is inside the assay’s variability and the interval you measured over is too short.

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u/freya_onwuka10 points·1 year ago

the diabetes trials report different endpoints from the obesity ones

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u/source_or_silence7 points·1 year ago

Not convinced. Hypoglycaemia risk from this class alone is low; the risk you are describing comes from the combination.

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u/hana_lehtinen17 points·1 year ago

That is a sensor value, not a plasma value, and the two are not interchangeable at that level of precision.

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u/bianca_demir21 points·1 year ago

Brought the whole CGM export to my appointment rather than one number. Entirely different conversation.

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u/adnan_karlsen5 points·1 year ago

sensor accuracy varies and the first day of a sensor is the worst

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Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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