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c/t2dglp1·submitted 1 months ago by u/joaquin_stanescu

the hypoglycaemia question that gets asked weekly, answered properly

Resultsbranch of 6 comments

Something I keep coming back to: the hypoglycaemia question that gets asked weekly, answered properly. My A1c moved and it turned out to have nothing to do with glucose at all. The order things move in, since nobody explains it and it worries people. Postprandial excursions generally respond earliest. Variability…

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6 comments, started 1 months ago
u/sigrid_kaufmann67 points·1 months ago

a single high reading is not a trend

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u/neha_falk22 points·1 months ago

Variability dropped before the average did, which was visible on the sensor and invisible on the lab result.

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u/kasper_cabrera12 points·1 months ago

the fasting number is the one people fixate on and it moves last

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u/britt_abubakar-14 points·1 months ago

Incretin-based agents stimulate insulin secretion in a glucose-dependent manner, which is why hypoglycaemia risk with them alone is low. Risk rises with agents that act independently of glycaemia.

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[deleted]25 points·1 months ago

[deleted]

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u/emil_okwuosa29 points·1 months ago

metformin and an incretin agonist are not in competition

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Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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