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c/semaglutide·submitted 6 months ago by u/source_or_silence

stalled for 21 weeks at 2.4mg and I refuse to panic this time

Titrationbranch of 8 comments

Something I keep coming back to: stalled for 21 weeks at 2.4mg and I refuse to panic this time. Since the title puts numbers in the shop window: 21 weeks and 2.4mg. On the "everybody ends up at 2.4" claim, which comes up every few weeks. The escalation schedule in the trials was designed to get people to a fixed…

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8 comments, started 6 months ago
u/ines_castellanos482 points·6 months ago

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.

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u/nausea_notesMOD299 points·6 months ago

Standard reminder: no personal titration plans for other members, and no medical advice. Everything else is fine.

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u/source_or_silenceOP176 points·6 months ago

Standard reminder: no personal titration plans for other members, and no medical advice.

nausea_notes is describing the standard shape here and it matches the trial data better than most anecdotes do.

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u/freya_baptista47 points·6 months ago

the first four weeks are a tolerance check, not a weight-loss phase

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u/vikram_ferreira47 points·6 months ago·edited

How long was the stall before you decided it was a stall?

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[removed]206 points·6 months ago

[removed by moderator]

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u/diego_sorensen166 points·6 months ago

Sceptical of the mechanism you are proposing. Gastric emptying slows, it does not stop, and the timings you describe do not follow from it.

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