[Results] 19 weeks, 7kg, and food noise was the hard part
19 weeks, 7kg, and food noise was the hard part, and the part I actually want to talk about is at the bottom.
Figures up front so nobody has to dig: 19 weeks and 7kg.
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
Ask me anything specific. Anything general I will probably get wrong.
best — the order this archive was captured in
Leaving this up. It is a check-in, it has numbers, and it is honest about being one person.
That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.
the first four weeks are a tolerance check, not a weight-loss phase
the first four weeks are a tolerance check, not a weight-loss phase
Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.
the scale is the least sensitive instrument you own
Yes — and the honest version is that most of the "it stopped working" posts turn out to be a normal fortnight of water weight.
What dose and how many weeks at it before this started?
the first four weeks are a tolerance check, not a weight-loss phase
This is the part I would underline for anyone skimming. Everything else in the thread is downstream of it.
This matches me almost exactly, right down to the constipation showing up on the second day and being gone by the fourth.
Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chem
Disagree with this specific line. A pause at 1.0mg is not evidence that 1.0mg has stopped working.
if 1.0mg is working there is no prize for going up
Cosigning. The appetite change and the scale change ran about three weeks apart for me too.
do not chase somebody else’s titration schedule, they are not you
2.4 is a ceiling, not a target
Minor fix — the half-life is about a week, not about a day. The rest of your point stands.
My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.
Not convinced. You changed the dose and the week at the same time, so you cannot attribute the change to either.
nausea that arrives on day two and fades by day four is the standard shape
sema is weekly for a reason, the half-life does the smoothing
- 1Research-use-only material is not approved for human use, so anything in…10 comments in this branch · started by u/bilal_osei
- 22.4 is a ceiling, not a target6 comments in this branch · started by u/anya_salgado