is it normal to get constipation at week 26
Check-in as promised in the title: is it normal to get constipation at week 26.
On the "everybody ends up at 2.4" claim, which comes up every few weeks.
The escalation schedule in the trials was designed to get people to a fixed study dose. Real use is not a trial. The dose that keeps your appetite quiet with side effects you can live with is the dose, and for a lot of people on this board that has been 1.0mg for a very long time.
The counter-argument, which is fair: some people genuinely do need the top of the range, and staying low out of caution costs them months. That is a conversation with someone who knows your history, not with us.
Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.
If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.
best — the order this archive was captured in
Removed the dose recommendation. You can describe what you did; you cannot tell somebody else what to take.
Yes. Week 7 is when almost everybody writes the "is it still working" post, and almost everybody is fine.
the first four weeks are a tolerance check, not a weight-loss phase
How long was the stall before you decided it was a stall?
Do sulphur burps track the day after the shot, or is it there all week?
Kept a log from week one and the single most useful column turned out to be waist, not weight.
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Correcting myself from earlier in the thread: I said week 12 and it was week 17. Same shape, wrong number.
The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.
The escalation schedule in the trials existed to keep people on the drug.
Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.
That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.
Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.
- 1Removed the dose recommendation. You can describe what you did; you cannot…9 comments in this branch · started by u/nausea_notes