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c/semaglutide·posted 21 days ago by u/georgi_haddad

oral 50mg vs injectable 2.4 — OASIS 1 numbers are closer than i expected

Titration Slow Clap ×9

Something I keep coming back to: oral 50mg vs injectable 2.4 — OASIS 1 numbers are closer than i expected.

Since the title puts numbers in the shop window: 50mg.

First month I lost almost nothing and nearly quit. Month two and three were where it all happened.

The appetite thing was the surprise. I expected to feel full. What I got was simply not thinking about food between meals.

If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.

751 up / 218 down78% upvoted21 commentsid 1gjtlf9 Jul 2026

21 comments

12 in this archive, depth 5

best — the order this archive was captured in

u/camila_mensa78 points·20 days ago

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.

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u/titration_marshalmod · c/semaglutide26 points·20 days ago

Minor fix — the half-life is about a week, not about a day. The rest of your point stands.

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u/reflux_report18 points·20 days ago

Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.

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u/pavel_nkemelu51 points·20 days ago

Not convinced. You changed the dose and the week at the same time, so you cannot attribute the change to either.

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u/quiet_moderatorMOD27 points·20 days ago

Leaving this up. It is a check-in, it has numbers, and it is honest about being one person.

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u/teodor_duarte38 points·20 days ago·edited

Sceptical of the mechanism you are proposing. Gastric emptying slows, it does not stop, and the timings you describe do not follow from it.

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u/camila_sandvik22 points·20 days ago

Yes — and the honest version is that most of the "it stopped working" posts turn out to be a normal fortnight of water weight.

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u/iman_castellanos13 points·19 days ago

Are you measuring anything other than weight? Waist is usually the one that keeps moving.

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u/hassan_castellanos10 points·18 days ago

Does fatigue track the day after the shot, or is it there all week?

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u/sorted_by_new3 points·18 days ago

I would push back gently. Going up because the scale paused is the single most common mistake described on this board.

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u/anya_salgado2 points·18 days ago

That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.

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u/alcohol_aversion0 points·18 days ago

STEP-1 averaged just under 15% at 68 weeks, so a 10% year is not a failure

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