[Results] 61 weeks, 34kg, one very boring spreadsheet
61 weeks, 34kg, one very boring spreadsheet, and the part I actually want to talk about is at the bottom.
Figures up front so nobody has to dig: 61 weeks and 34kg.
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
Corrections welcome, especially the pedantic ones. Pedantry is how this board earns its reputation.
best — the order this archive was captured in
Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the reflux usually fades at a stable dose.
Minor fix — the half-life is about a week, not about a day. The rest of your point stands.
I would push back gently. Going up because the scale paused is the single most common mistake described on this board.
That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.
Yes. Week 19 is when almost everybody writes the "is it still working" post, and almost everybody is fine.
Same. I sat at 0.25mg for three months because it was working and there was nothing to fix.
The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.
Are you measuring anything other than weight? Waist is usually the one that keeps moving.
The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.
That reads like a titration plan and this board cannot give you one. Somebody who actually knows your history has to.
Cosigning. The appetite change and the scale change ran about three weeks apart for me too.
Cosigning.
plain_titration is describing the standard shape here and it matches the trial data better than most anecdotes do.
Careful. A four-week stall is inside normal variation and treating it as failure is how people escalate for no reason.
Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.