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c/semaglutide·submitted 3 months ago by u/boots_or_bust

[PSA] Ozempic is not what most of this community thinks it is

PSAbranch of 7 comments

The one-line version is the title: Ozempic is not what most of this community thinks it is. The rest is why. The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little. Delayed gastric…

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7 comments, started 3 months ago
u/hassan_ostergaard313 points·3 months ago

The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.

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u/source_or_silence-4 points·3 months ago

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.

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u/adnan_karlsen1 point·3 months ago

Minor fix — the half-life is about a week, not about a day. The rest of your point stands.

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u/throwaway_titration1 point·3 months ago

Agreed, and the bit people skip is that the ladder is a tolerance ladder. It is not a potency ranking.

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u/boots_or_bustOP1 point·3 months ago

staying at 1.7mg for an extra month is a legitimate plan

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u/kenji_demir1 point·3 months ago

Strongly agree on protein. It did more for my reflux than any of the things I bought to fix my reflux.

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u/leila_silva2 points·3 months ago

stalling at 0.5mg is information, not a verdict

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