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c/semaglutide·posted 2 years ago by u/kenji_vasquez

[Discussion] the Ozempic advice in here is 2 years out of date

Discussion

the Ozempic advice in here is 2 years out of date, and I am aware this is a minority view on this board.

Hard numbers: 2 years. Anything softer than that is flagged as an impression.

The appetite thing was the surprise. I expected to feel full. What I got was simply not thinking about food between meals.

First month I lost almost nothing and nearly quit. Month two and three were where it all happened.

Sceptical readings welcome. The confident ones are the ones I distrust.

92 up / 126 down42% upvoted8 commentsid 14366b4 Feb 2024

8 comments

8 in this archive, depth 2

best — the order this archive was captured in

u/vikram_ferreira6 points·2 years ago

Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.

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u/nausea_notesside effects5 points·2 years ago

The mental model that finally made this click for me: there are two curves, and people watch the wrong one.

The first is exposure, which is set by the dose and smoothed by a week-long half-life. It changes when you change the dose and then settles over about a month. The second is body weight, which is exposure filtered through appetite, food, water, sleep, training and the scale itself, and which moves in steps rather than a line.

Almost every "it stopped working" post is somebody watching curve two over a fortnight and drawing conclusions about curve one. If the appetite effect is still there, exposure is fine. Wait the month.

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u/noor_hovland3 points·2 years ago

Kept a log from week one and the single most useful column turned out to be waist, not weight.

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u/kenji_vasquezOP1 point·2 years ago

the appetite signal and the scale move on different clocks

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u/kenji_vasquezOP2 points·2 years ago

My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.

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u/kenji_vasquez2 points·2 years ago

Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.

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u/reflux_report2 points·2 years ago

Same injection day each week, or has it drifted?

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u/elodie_grimaldi1 point·2 years ago

Does early fullness track the day after the shot, or is it there all week?

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